PTGS2 and periodontitis: However, another study suggests that a H2S-releasing ketoprofen drug, ATB-352, can prevent the LPS-induced periodontitis and associated bone resorption in rats by reducing inflammation, apoptosis, and ROS through attenuating the IL-1β, TNF-α, NF-κB, Bax, cyclooxygenase-2 (COX-2), and iNOS expressions, myeloperoxidase activities, and tartrate-resistant acid phosphatase positive cells as well as upregulating Bcl-2 [94].