The results demonstrated that the mRNA levels of psoriasis-related cytokines, namely, IL-22 and IL-23, were significantly decreased in the group treated with 5 mg of pinocembrin compared with the vehicle-treated group (F-value = 101 and p = 0.0209 for IL-22; F-value = 1.83 and p = 0.0338 for IL-23; Figure 8). This evidence concerns the gene IL22 and psoriasis.