Aberrant expression of FZD8 has been reported in gastric cancer, prostate cancer, renal cell carcinoma, lung cancer, pancreatic adenocarcinoma, and overexpression of FZD8 was considered to promote tumor metastasis (Li et al., 2017; Yang et al., 2017; Liu et al., 2019; Chen et al., 2020; Li et al., 2021). This evidence concerns the gene FZD8 and Familial prostate cancer.