Circ-VAMP3 expression is significantly increased in ARMS cells, and knockdown of circVAMP3 regulates the CCNB1/CDK1 complex, which controls the G2/M checkpoint by promoting the expression of CDKN1A and WEE1, thus the AKK1 and CDK1 complexes, as well as downregulation of Akt and ERK1, thereby inhibiting the cell cycle (Rossi et al., 2021). The gene discussed is CDK1; the disease is alveolar rhabdomyosarcoma.