The subject operating characteristic (ROC) curve was applied to investigate the diagnostic value of circ-HMGCS1 in distinguishing HB tissue from normative tissue showing that circ-HMGCS1 had diagnostic value (Area Under Curve (AUC) = 0.8283), with high expression of circ-HMGCS1 predicting poor prognosis in HB patients by Kaplan-Meier survival curve analysis (Zhen et al., 2019). This evidence concerns the gene HMGCS1 and hemoglobin measurement.