APC and diffuse large B-cell lymphoma: Mechanistic studies revealed that circ-APC acts as a sponge for miR-888 in the cytoplasm to upregulate APC, whereas, in the nucleus, circ-APC binds to the APC promoter and recruits the DNA demethylase TET1, which transcriptionally upregulates APC, thereby inhibiting the typical Wnt/β-catenin signaling pathway by reducing the accumulation of β-catenin in the nucleus and the catenin signaling pathway by reducing the accumulation of β-catenin in the nucleus, retarding the growth of DLBCL (Hu et al., 2019).