For instance, gene sets related to pathways such as PIK3 cascade (“PI-3K cascade: FGFR1”, “PI-3K cascade: FGFR2”, “PI-3K cascade: FGFR3”, “PI3K events in ERBB4”, “PI3K/AKT Signaling in Cancer”) and TP53 pathway (“p53 pathway feedback loops 2”, “p53 pathway”) frequently appeared among the most significant results. The gene discussed is TP53; the disease is cancer.