In addition, the fact that PDE4B inhibition induces myopia and exacerbates FDM (Tao et al., 2013; Zhao et al., 2021) together with its genetic susceptibility role provide additional indications that loss of PDE4B gene function serves as a noteworthy model for evaluating the interaction between genetic and environmental factors in myopia development. This evidence concerns the gene PDE4B and myopia.