AKT1 and serum lipopolysaccharide activity: In addition, HSP70 plays a key role in the process of heat resistance by maintaining cell homeostasis (256, 257) as it can protect cells from endotoxemia, hypoxia, and metabolic stress (258); inhibit the activation of caspase3 to prevent heat stress-induced cells apoptosis (259, 260); and activate protein kinase B (Akt) to promote cell survival (261).