CD4 and systemic lupus erythematosus: Targeting immunogenic self-DNA-specific Tfh cells through human RORγ knockdown in CD4+ T cells and IL-17 neutralization effectively eliminated the levels of kidney inflammation, IgG deposition, and proteinuria in humanized SLE mice (8 weeks old NSG mice engrafted with 1×107 PBMCs/mouse from patients with SLE) (23).