For the autoantibodies produced by this PBLs/PBMCs humanized SLE mouse model, several main autoantigens (e.g., dsDNA, Ro, RNP, anti-La, etc.), and subtypes of IgGs (e.g., IgG I, IgG II) can be detected. The gene discussed is RNPC3; the disease is systemic lupus erythematosus.