Treatment with hCDR1 significantly decreased the serum levels of human anti-dsDNA antibodies and decreased the serum levels of IFN-γ and IL-10, while increasing TGF-β production in humanized SLE mice (8–10 weeks old SCID mice engrafted with 3×107 PBLs/mouse from patients with SLE) (29). Here, TGFB1 is linked to systemic lupus erythematosus.