IL6 and systemic lupus erythematosus: In addition, treatment of humanized SLE mice (6–10 weeks old SCID mice engrafted with 1.5×107 PBMCs/mouse from patients with SLE) with an anti-IL-6 monoclonal antibody inconsistently decreased the serum concentration of anti-dsDNA IgG produced by PBMCs from patients with SLE.