Interestingly, the accumulation of mature macrophages presenting the tumor cell-derived antigen within the draining lymph nodes of mice controlling tumor cell growth after SuperMApo treatment was correlated with the reduction of peripheral pro-tumoral macrophages, as attested by significant reduced blood counts of IL-6+, TNF-α+, CD206+, and PDL1+ macrophage subsets (Figure 4 and Supplementary Figure S5). Here, TNF is linked to neoplasm.