Many studies have demonstrated that the Toll and IMD signaling pathways can inhibit viral and bacterial infections by regulating the expression of AMPs (such as crustin (93, 94), penaeidin (95, 96), anti-lipopolysaccharide (anti-LPS) factor (97–99), and lysozyme (100, 101), promoting apoptosis (102–104) and producing ROS (105). The gene discussed is ADSL; the disease is bacterial infectious disease.