Moreover, the hierarchical clustering and heatmap for genes specific for NK cells and PMN-MDSC in 57 lung adenocarcinoma samples and 57-matched normal samples retrieved from TCGA indicated that genes specific for NK cells were enriched in normal tissue while genes specific (S100A9 and CD15) for PMN-MDSC were more expressed in the tumor tissues (Figure 1C). This evidence concerns the gene S100A9 and neoplasm.