CD8A and COVID-19–associated multisystem inflammatory syndrome in children: Recent studies have shown an association between development of MIS-C and expansion of Vbeta 21.3+ CD4+ and CD8+ T cells, activation of vascular patrolling CX3CR1+ CD8+ T cells, putative autoantibody expression, and decreased numbers of tolerogenic dendritic cells, though its cause remains undefined (7, 11–14).