GISTIC 2.0 analysis revealed that in gliomas with high-risk scores, the amplification mainly occurred in chromosomal regions 1q32.1, 3q26.33, 4q12, 7p11.2, and 12q14.1, where several key oncogenes (PDGFRA, EGFR, MDM2, SOX2, and CDK4) were located. The gene discussed is MDM2; the disease is glioma.