Analysis of the TCGA dataset showed that ALDH16A1, ALDH3B1, ALDH1A3, ALDH3A1, ALDH7A1 were significantly increased in IDH wildtype gliomas, while ALDH2, ALDH6A1, ALDH5A1, ALDH1A1, ALDH1L2, ALDH18A1, ALDH1B1 expression were higher in IDH mutant gliomas than IDH wildtype gliomas (Figure S1E). This evidence concerns the gene ALDH6A1 and central nervous system cancer.