If this coincides with other GH- and IGF-1-induced problems (such as overstimulation of the smooth muscle tissue in small blood vessels and the resulting fibrosis, vasoconstriction, insulin resistance, hyperinsulinemia, and excessive sympathetic system activation), the risk of inadequately controlled AH increases considerably (7, 38, 41). The gene discussed is IGF1; the disease is Hyperinsulinemia.