Recent studies identified KCNT1 as a novel driver of pathogenesis in some types of refractory epilepsy (e.g., epilepsy of infancy with migrating focal seizures, autosomal dominant nocturnal frontal lobe epilepsy, West syndrome, Ohtahara syndrome, early myoclonic encephalopathy, focal epilepsy, and multifocal epilepsy) (4–6). Here, KCNT1 is linked to early-infantile DEE.