Interestingly, some reports have also identified C9orf72 patients with ALS and FTD presenting with cognitive impairment but with minimally TDP-43 inclusions underscoring the influence of other physiopathological mechanisms such as dipeptide repeat accumulation and RNA foci in the appearance of cognitive impairment (63, 108). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.