Similarly, genes such as TANK-binding kinase-1 (TBK1) (65–69), Sequestosome-1 or p62 (SQTSM1) (70), Optineurine protein (OPTN), and Valosin-containing protein (VCP) that are associated with FTD, inclusion body myositis, motor neuron disease, and Paget's disease encode proteins related to protein degradation (71, 72). This evidence concerns the gene SQSTM1 and motor neuron disorder.