Similarly, genes such as TANK-binding kinase-1 (TBK1) (65–69), Sequestosome-1 or p62 (SQTSM1) (70), Optineurine protein (OPTN), and Valosin-containing protein (VCP) that are associated with FTD, inclusion body myositis, motor neuron disease, and Paget's disease encode proteins related to protein degradation (71, 72). Here, SQSTM1 is linked to Paget disease.