Expression of HSP90 was decreased in animals treated with fluoride (Panneerselvam et al., 2017), and no significant change was observed after CAL in comparison with control group (Tanonaka et al., 2001a), whereas expression of HSP90 increased in patients with DCM (Kapustian et al., 2013). The gene discussed is HSP90AB1; the disease is familial dilated cardiomyopathy.