Decoctions like Xiaoyaosan can inhibit expression of HSP27, HSP60 and HSP90, and promote interaction of HSP90 with glucocorticoid receptor (GR) and CD36 to prevent development of atherosclerotic vulnerable plaque in mouse model of atherosclerosis induced by high-fat food coupled with chronic stress (Fu et al., 2019). Here, HSP90AA1 is linked to atherosclerosis.