HSPB1 and hydrops fetalis: HSP27 may possibly have a dual effect on HF; it not only acts as an antioxidant to protect the heart from damages and improve cardiac function (Liu et al., 2007a; Turakhia et al., 2007; You et al., 2009), but also augments injury in a failing heart (Vedam et al., 2010; Zhang et al., 2010; Yu et al., 2015).