HSP90 facilitates regulation of Raf/Mek/ERK, transformation of growth factor-β (TGF-β) and NF-κB pathways in cardiac hypertrophy which are either induced by MI or pressure overload (Lee et al., 2010; Datta et al., 2015; Tamura et al., 2019). The gene discussed is RAF1; the disease is cardiac hypertrophy.