ATG5 and Hepatitis: Notably, JWH-133 reduced the expression of lipopolysaccharide (LPS)-induced inflammatory genes in autophagy related protein 5 (ATG5)-sufficient macrophages but not in ATG5-deficient cells, and JWH-133 treatment also protected mice from alcohol-induced liver inflammation and steatosis but was not protective in mice lacking ATG5 in myeloid cells (Denaës et al., 2016).