NLRP3 and type 1 diabetes mellitus: Inflammatory components of the innate immune system such as toll-like receptors (TLRs), NLRP3 (NLR family pyrin domain containing 3) inflammasome, and IL-1β contribute to the etiology of T1DM and their activation recruits inflammatory T cells and macrophages into islets where they are cytotoxic to β-cells (Grishman et al., 2012).