INS and autoimmune disease: Several human leukocyte antigen (HLA) gene polymorphisms of MHC class I and II (Noble and Valdes, 2011), insulin gene short VNTR (variable number tandem repeat) (Bennett et al., 1995), and a nonsynonymous CNR2 SNP (Q63R) are risk alleles that co-segregate with several autoimmune diseases (Rossi et al., 2012; Mahmoud Gouda and Mohamed Kamel, 2013; Bellini et al., 2015; Ismail and Khawaja, 2018; Strisciuglio et al., 2018).