In order to eventually answer this, we have created Cnr2-floxed mice that can be crossed with CX3CR1-Cre and CD11C-Cre mice to generate M1/M2-macrophages and F4/80+CD11c+ obesity-associated dendritic cell specific conditional CB2 knockout mice so that we can study macrophage activation and intercellular extracellular vesicle signaling and trafficking between adipocytes, β-cells and APCs (Liu et al., 2020a). Here, CNR2 is linked to obesity due to melanocortin 4 receptor deficiency.