CNR1 and obesity due to melanocortin 4 receptor deficiency: The dynamic ranges of CB1R and CB2R mRNA levels from CNS to peripheral tissues are among the highest of the GPCR superfamily (Liu et al., 2020a) and CB2R is more inducible than is CB1R in the setting of obesity-related inflammation (Yu et al., 2015; Wu et al., 2020b).