The possible hypoglycemic pathway exerts its action by enhancing the activities of bioenzymes such as hexokinase and pyruvate kinase during glycolysis by increasing the content of liver glycogen and inhibit the gene expression of glucose-6-phosphatase and phosphoenolpyruvate carboxylase, which are key enzymes in the process of liver gluconeogenesis, and to maintain insulin resistance (Prasath and Subramanian, 2011; Prasath et al., 2014). This evidence concerns the gene PCK1 and Insulin resistance.