IL1B and infarction: Inflammation plays a pivotal role in the acute early response, which initiates subsequent repair and acts as a “sentinel.” Macrophages are activated immune-cells in early phase post infarction that secrete various cytokines and are intimately correlated with the activation of cardiac fibroblast, initiating “macrophage-fibroblast crosstalk.” Pro-inflammatory activation of cardiac fibroblasts is associated with inflammasome induction, which leads to caspase stimulation and IL-1β secretion by macrophages (Kawaguchi et al., 2011), (Sandanger et al., 2013).