POSTN and myocardial infarction: In addition, we conducted immunostaining on MI segments using periostin to verify cardiac myofibroblast enrichment and collagen deposition, revealing significantly decreased periostin+ cell expression within MI segment in Curcumin group (Figures 2F,G), western blot results also confirmed the therapeutic utilization of Curcumin in inhibiting pro-fibrotic protein expression as displayed by ameliorated Periostin, Vimentin, and α-SMA expression (Figure 2H–K).