Furthermore, MCL treatment reduced the expression of Casp1 p20 and GSDMD-N, thereby inhibiting pyroptosis in RIE, suggesting that the therapeutic effects of MCL may be mediated by inhibition of the NLRP3 inflammasome (Gong et al., 2019; Sui et al., 2020). This evidence concerns the gene CASP1 and mantle cell lymphoma.