ANXA5 and colorectal carcinoma: Annexin V assay revealed apoptotic induction in OTS514-treated CRC cells: 1.6 to 2.3 fold increase in early apoptosis (p < 0.01) in SW48, HCT116 and LoVo; 1.9 and 4.2 fold increase in late apoptosis (p < 0.01) in SW48 and HCT116, respectively (Table 2 and Figure 2D).