PBK has also been reported to enhance the malignant potential of cells, such as by promoting cellular proliferation of tumor cells, and its expression in malignant tumors such as multiple myeloma is associated with patient survival (Brown-Clay et al., 2015; Kwon et al., 2016; Ohashi et al., 2016; Ohashi et al., 2017; Yang et al., 2017; Ota et al., 2020). This evidence concerns the gene PBK and AL amyloidosis.