HMGB1 and Hepatic fibrosis: Previous studies have indicated that quercetin ameliorates CCl4-induced liver fibrosis via the HMGB1-TLR2/4-NF-κB, NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling pathways (Li et al., 2016b; Wang et al., 2017) and that luteolin can reverse the liver fibrosis in mice induced by CCl4 (Domitrović et al., 2009).