IGF1 and post-traumatic stress disorder: Conversely, administration of AICAR, an AMPK agonist [44], to IGF-I-treated PTSD mice (Fig. 4K) abolished the protective action of this growth factor (n = 8 mice/group, One-way-ANOVA followed by Tukey’s; Fig. 4L-O), corroborating a role of AMPK in IGF-I actions.