While both Firoc and littermates responded similarly to rat exposure (n = 6–8 group; Two-way-ANOVA, F (genotype) = 0.7030, P = 0.4108), after IGF-I treatment, anxiety was reduced in littermates compared to vehicle-treated ones (Two-way ANOVA, F (treatment) = 5.698, P = 0.0260; F (interaction) = 8.740, P = 0.0073; followed by Tukey’s multiple comparisons test, q (control vehicle vs control IGF-I) = 2.051, p = 0.0039), but not in Firoc mice. The gene discussed is IGF1; the disease is Anxiety.