Indeed, Firoc mice developed PTSD-like behaviors [54] after fear conditioning, display changes in gene expression in various brain areas reminiscent of changes seen in other experimental models of PTSD (not shown), and showed a decreased VGlut2/Vgat ratio onto the soma of orexin neurons, suggesting reduced glutamatergic (excitatory) inputs and increased GABAergic (inhibitory) inputs. This evidence concerns the gene HCRT and post-traumatic stress disorder.