Other than the disease-related pathways, several other critical pathways involved in physiology and pathology like cytokine-cytokine receptor interaction, transcriptional misregulation in cancer, viral protein interaction with cytokine and cytokine receptor, NF-kB signaling pathway, Toll-like receptor (TLR) signaling pathway and others were significantly affected in one or two of the three comparison sets (Fig. 5, upper panel). Here, NFKB1 is linked to cancer.