Pathway analysis in M2-MDMs showed that IFN-λ3 treatment on differentiating macrophages had led to differential expression of genes that were important in several infectious diseases including tuberculosis, salmonellosis, toxoplasmosis, amoebiasis, legionellosis, pertussis, and leishmaniasis (Fig. 6, upper panel). This evidence concerns the gene IFNL3 and infectious disease.