Amoebiasis, rheumatoid arthritis, S. aureus infection and legionellosis were some of the top pathways affected in M1-MDMs differentiated in presence of IFN-λ3; amoebiasis, rheumatoid arthritis, small cell lung cancer, and legionellosis were affected by IFN-λ4 in M1-MDMs, while amoebiasis, rheumatoid arthritis, and legionellosis were also affected pathways when IFN-λ4 vs. IFN-λ3 gene sets were analyzed. The gene discussed is IFNL3; the disease is legionellosis.