For example, an increase in input resistance due to the administration of 77-LH-28-1 could facilitate spike backpropagation, potentially rescuing the plasticity impairment and network dysfunctions reported in the Cacna1c+/− and 22q11 deletion syndrome models of genetic vulnerability to schizophrenia [80, 78], Highly selective muscarinic M1 receptor agonists have efficacy clinically with negligible side effects [81–84] making them attractive pharmaceutical tools. This evidence concerns the gene CACNA1C and schizophrenia.