Nonetheless, the relationships of ACE2 and TMPRSS2 with histological, transcriptomic and genomic HCC subclasses converge to demonstrate that tumors preserving hepatocyte-like features, such as hepatocyte trabeculae with bile canaliculi and/or pseudo-glandular structures with an apical biliary pole, express higher levels of the SARS-CoV-2 receptor and co-receptor couple. This evidence concerns the gene TMPRSS2 and hepatocellular carcinoma.