IGFBP3 and type 2 diabetes mellitus: Interestingly, the analysis of glycometabolic parameters in a cohort of individuals at risk for T2D and enrolled within a subgroup of the GENFIEV study revealed that peripheral IGFBP3 levels were higher in patients with 1-h OGTT (oral glucose tolerance test) plasma glucose level >155 mg/dl, which is a strong predictor of T2D development (Fig. 2d).