Consistently, the frequency of RIPK2 protein overexpression is positively associated with Gleason scores (a predictor of PC recurrence), ranging from 3.7% in tumor-adjacent normal tissue to 26.7% in tumors with the Gleason score of 9 (Fig. 1e and Supplementary Fig. 1f, g). The gene discussed is RIPK2; the disease is neoplasm.