RIPK2 and pachyonychia congenita: RIPK2 mRNA levels are significantly higher in aggressive PC subtypes such as Prostate Cancer Subtype 1 (PCS1) and Luminal B (LumB)24,29, compared with the other two less aggressive PCS or PAM50 (prediction analysis of microarray 50) subtypes, in both PCTA and The Cancer Genome Atlas (TCGA) Firehose Legacy cohorts (Fig. 1g and Supplementary Fig. 1h, respectively).