Consistent with the clinical findings, RIPK2 protein abundance is substantially higher in PC cell line models capable of forming metastases in immunocompromised mice, such as PC3, DU145, 22Rv1, and LNCaP, compared with non-metastatic prostate cell lines such as RWPE-2 and RWPE-1 (Fig. 1f). Here, RIPK2 is linked to pachyonychia congenita.