RIPK2 and pachyonychia congenita: To investigate whether pharmacological inhibition of RIPK2 can suppress PC metastasis in a setting that mimics the clinical scenario, we injected the aforementioned luciferase-tagged control 22Rv1 cells intracardially into male SCID/Beige mice and waited for 9 days to allow for the formation of early metastatic lesions, prior to drug treatment (Fig. 8g).