Finally, regarding the CARTPT SNP rs3846659, in women with the GG genotype, compared to the lowest IGFBP-3 serum concentration tertile, women in the highest tertile showed an increased BC risk, but this effect was lost in the presence of the minor allele C. In a previous work, our group found that rs3846659 was associated with the risk of premenopausal BC11. The gene discussed is IGFBP3; the disease is breast cancer.