IGFBP3 and breast cancer: Our results show that the positive effect of the IGFBP-3 highest serum concentration tertile on the BC risk observed in women with the GG decreased in the presence of the minor allele A. Interestingly, it has been reported that rs12059300 interacts with methylation sites in the 5 ́UTR of LEPR, influencing LEP serum levels (LEP levels decrease for AA compared to the GG genotype)41.