In our study, seven SNPs in five genes (MBOAT4 rs13272159, NPY rs16131, ADIPOQ rs182052, rs822391 and rs7649121, CARTPT rs3846659, and LEPR rs12059300) showed a significant modifying effect (Pinteraction < 0.05; adjusted Pinteraction < 0.20), with at least one tertile of IGF-1 or IGFBP-3 associated with the risk of BC (P value < 0.05). This evidence concerns the gene IGFBP3 and breast cancer.