For seven SNPs (ADIPOQ rs822391, rs3821799, and rs3774261; CARTPT rs3846659; LEPR rs12059300; NPY rs16141 and rs16129), when comparing the effect of the highest IGFBP-3 serum concentration tertile vs. the lowest, there was a statistically significant increased BC risk in those who were homozygous for the major allele. This evidence concerns the gene LEPR and breast cancer.