The role of radixin in CKD has not been explored although other ERM proteins have been associated with regulation of fibrosis57,58, FDX1 encoding for Ferrodoxin 1 is a small iron sulfur protein important for electron transfer particularly to cytochrome P450 enzymes and iron homeostasis and has also been implicated in Vitamin D homeostasis via CYP enzymes59,60. The gene discussed is ETV5; the disease is chronic kidney disease.