A mTORC2 inhibitor, JR-AB2-011, reversed the effects of anti-miR-582 on AKT and FoxO1 phosphorylation (Fig. 7B), and abrogated increased pre-B cell proliferation and survival upon anti-miR-582 lentivirus infection (Fig. 7C). This evidence concerns the gene FOXO1 and lentivirus infection.