Western blot analysis showed that the expression of REV1, Rad18, RPA32 and REV7 was markedly elevated in several lung cancer cell lines (A549, H1299, Calu-1, and SPC-A1) compared with the normal bronchial epithelial cells HBE (Fig. 1D, Supplementary Fig. 2). This evidence concerns the gene REV1 and lung carcinoma.