To determine the specificity of JH-RE-06, we used JH-RE-06 to treat REV1 silencing cells and found that the inhibitory effect of REV1 silencing on the growth and proliferation of lung cancer cells could not be further enhanced, indicating that JH-RE-06 functions in a REV1-dependent manner (Fig. 2G, H). The gene discussed is REV1; the disease is lung cancer.