CD8A and neoplasm: In addition, the CCK8 assay (Fig. 4D) showed that silencing LINC01123 or B7–H3 expression in CAL-27 cells or miR-214-3p-mimic treatment of CAL-27 cells enhanced the tumor-cell-killing effect of CD8+T cells (P < 0.05), while LINC01123 overexpression or miR-214-3p inhibitor led to the opposite (P < 0.05).