HNSCC cells transfected with sh-LINC01123, sh-B7–H3, or the miR-214-3p mimic exhibited higher levels of TNF-α, IFN-γ, perforin, and granzyme B (P < 0.05), and cells treated with OE-LINC01123 or the miR-214-3p inhibitor led to the opposite result (P < 0.05). Here, IFNG is linked to head and neck squamous cell carcinoma.