EMX1 and Anxiety: When tested in the elevated plus maze, St8sia2−/− mice in cohort 2 showed signs of reduced anxiety that were fully reproduced by Foxb1-Cre;St8sia2f/f and, for the time spent in the closed relative to the open arm, also by Foxb1-Cre;Emx1-Cre;St8sia2f/f mice (Fig. 5b).