A previous study reported that Src phosphorylates LDHA at tyrosine 10 in breast cancer.30 And shRNA of CYTL1 or NDUFV1 led to a significant increase in lactate production in MDA-MB-231 cells, which was completely reversed by the Src kinase inhibitor KX2-391 (Supplementary Fig. S17). This evidence concerns the gene NDUFV1 and breast carcinoma.