LDHA, a critical metabolic enzyme in glycolysis, catalyzes the interconversion of pyruvate and lactate and promotes tumor progression.27 Given the significant reduction in lactate production in breast cancer cells overexpressing CYTL1, we investigated whether intracellular CYTL1 influences LDHA enzymatic activity by stabilizing NDUFV1. The gene discussed is NDUFV1; the disease is breast cancer.