A recent study has shown that enhanced Gq signaling via chemogenetic hM3Dq-DREADD-mediated activation of CaMKIIα-positive forebrain excitatory neurons during the postnatal, but not the juvenile or adult, temporal windows results in long-lasting increases in anxiety- and despair-like behavior, accompanied by perturbed sensorimotor gating and PPI deficits (Pati et al., 2020). The gene discussed is CAMK2A; the disease is Anxiety.