CAMK2A and Anxiety: Together, these findings indicate that PNCNO-mediated, chronic hM4Di-DREADD inhibition of CaMKIIα-positive forebrain excitatory neurons during the early postnatal window does not appear to significantly influence anxiety-like behavior in adulthood on the OFT, EPM test, and LD test in both male and female CaMKIIα-tTA::TRE-hM4Di bigenic mice.