GNAI1 and Anxiety: It has been hypothesized that early stress may shift the balance toward enhanced excitatory Gq-coupled signaling accompanied by a decline in inhibitory Gi-coupled signaling in forebrain neurocircuits, which could contribute to the programming of perturbed anxiety- and despair-like behaviors (Sumner et al., 2008; Lambe et al., 2011; Tiwari et al., 2021).