Indeed, hyperexcitation of Emx1-positive neurons from P4 to P14 in the neocortex using either a noninvasive bioluminescent chemogenetics approach (Medendorp et al., 2021) or hM3Dq-DREADD-mediated activation of CaMKIIα-positive forebrain excitatory neurons from P2 to P14 (Pati et al., 2020) resulted in enhanced anxiety-like behaviors and perturbed social behavior. This evidence concerns the gene CAMK2A and Anxiety.