TNF and peripheral neuropathy: For example, in the mouse model of cisplatin-induced peripheral neuropathy, inhibition of the triggering receptor expressed on myeloid cells 2 (TREM2) by an anti-TREM2 neutralizing antibody induced a decrease of TNF-α, IL-1β, IL-6, iNOS, and CD16 in the spinal cord and an increase of IL-4, IL-10 and CD206 [27].