Three associated variants were within the Ig V-set (variable) domain (Fig. 1), including CEACAM1:p.(Y68C) and CEACAM4:p.(R123E), which were associated with European American CRC risk, and CEACAM3:p.(Y95N), which was associated with African American CRC risk (Fig. 1). Here, CEACAM4 is linked to colorectal carcinoma.