Gu et al. found that low expression of METT14 in BC and bladder tumor-initiating cells (TICs), decreased m6A levels, and m6A levels were associated with clinical severity and prognosis. Knockout of METTL14 enhances Notch1 expression and stability, promoting the development of BC and bladder TIC self-renewal [104]. The gene discussed is METTL14; the disease is breast cancer.