METTL14 and nonpapillary renal cell carcinoma: METTL14 may be an independent prognostic indicator of RCC and ccRCC in univariate and multivariate Cox regression analyses [117–120]. The reduced METTL14 expression predicts a poor prognosis of the tumor. Studies have suggested that in RCC, the miRNA/mRNA-hsa-miR-1307- 3p/METTL14 pathway may regulate the occurrence and development of tumors and play an important role in clinical applications [121].