Liu et al. found that the R298P mutation in the key component of METTL14 leads to a reduction in m6A methylation and activation of the AKT pathway, thereby promoting the proliferation and migration of endometrial cancer cells. The increase in AKT activity depended on the decrease in PHLPP2 expression and the increase in mTORC2 expression [102]. The gene discussed is AKT1; the disease is endometrial cancer.