Gong et al. confirmed that knockdown of METTL14 reduced m6A levels and increased mRNA and protein levels of P2RX6, which then promoted the migration and invasion of RCC through the ATP-P2RX6-Ca2+-P-ERK1/2-MMP9 signaling pathway [115]. Liu et al. found that METTL14 inhibited the proliferation and migration of renal carcinoma by inhibiting the expression of long noncoding RNA nuclear enriched abundant transcript 1_1 (NEAT1_1) by YTHDF2 [116]. This evidence concerns the gene METTL14 and renal cell carcinoma.