Congenital anomalies of the kidney and urinary tract (CAKUT) have been reported rarer in STS limited microdeletions or point mutations than in larger deletions of Xp22.3 that encompass also the KAL1 gene, a neighboring gene important for urogenital development [7, 12, 13, 17, 18]. The gene discussed is ANOS1; the disease is congenital anomaly of kidney and urinary tract.