Since AMER-1 acts as a scaffold protein that recruits APC to consist of the β-catenin destruction complex, we believe that IRF-2 functions as a tumor suppressor gene in GC and that the axis of IRF-2-AMER-1/β-catenin plays an important role in the phenotype of cell proliferation (Fig. 6). This evidence concerns the gene IRF2 and neoplasm.