Qi demonstrated that IRF-2 is a transcription factor of CENP-N that promotes CENP-N expression and activates the AKT cascade in nasopharyngeal cancer [19], while Liao proved that IRF-2 binds to the DNA promoter region of CXCL3 and blocks its transcription in colorectal cancer [9]. The gene discussed is CENPN; the disease is nasopharyngeal carcinoma.