Besides, the integration of the SMAD4-PΨg in the SCAI gene has been corroborated in hereditary cancer-predisposition cases [27], and while SCAI is characterized to have suppressive effect on tumor cell invasiveness, it has not been determined whether SCAI expression is hindered by the SMAD4-PΨg [28]. This evidence concerns the gene SMAD4 and neoplasm.