However, mice injected to LV-CTRP3 could reverse the inhibitory effects of I/R injury on LVEF and LVFS levels and protein levels of CTRP3, LAMP1, JIP2 and p-JNK, and the promotive effects on myocardial infarct volume, apoptosis, and the contents of ROS, MDA and c-Tn1 (P < 0.05). Here, MAPK8IP2 is linked to myocardial infarction.