In association with this observation, trends towards increases in plasma Ang II and renin concentrations occurred in SCD mice on enalapril therapy, compared to enalapril-treated CON mice, indicating that the beneficial effects of enalapril in SCD on albuminuria and the prevention of cardiac remodeling [62, 63] may in fact be independent of ACE inhibition. This evidence concerns the gene ACE and Schnyder corneal dystrophy.