LCN2 and Schnyder corneal dystrophy: Although clear evidence of a nephroprotective effect of enalapril was not observed, five weeks of 25 mg/kg/day enalapril therapy did not significantly alter Lcn2 or Mmp9 expression in CON kidneys, but was associated with a non-significant decrease in the renal expressions of these genes in SCD mice (Fig 5H–5J).