Recent research suggests that increased neutrophil counts contribute to tumor growth and metastasis by releasing chemokines (CK) like IL-8, angiopoietin-1, matrix metalloproteinase-9, and vascular endothelial growth factor (VEGF), which are responsible for the formation of macular edema in some retinal vascular diseases [32,33]. Here, MMP9 is linked to macular retinal edema.