Several factors related to the prognosis of LC have been reported, such as the Child–Pugh grade [1], model for end-stage liver disease (MELD) score [1], renal impairment [11], liver stiffness (ultrasound-based transient elastography or magnetic resonance elastography) [12, 13], the combination of liver stiffness and MELD score [14], hepatic venous pressure gradient [15], sarcopenia [16], and albumin–bilirubin (ALBI) score [17]; however, these factors do not assess the course of progression. This evidence concerns the gene ALB and laryngotracheoesophageal cleft.