Concerning the role of regulatory adaptive cells, it was shown that helminth parasite–infected MS patients show a better disease outcome associated with an increase in CD4+ CD25+ Foxp3+ Treg cell frequency, IL-10 and TGF-β production, and a decrease in IL-12 and IFN-γ–secreting cells compared to noninfected patients [5,6,57]. This evidence concerns the gene CD4 and myeloid sarcoma.