ACE and colorectal cancer: Further, this meta-analysis did not include data from an earlier large Danish population-based case–control analysis with 15,560 colorectal cancer cases and 62,525 controls, which reported an increased risk of colorectal cancer (OR 1.30, 95% CI 1.22 to 1.39) among long-term users of ACE inhibitors (≥1,000 daily doses within 5 years of study entry), as compared to never-users [7].