To define the role of DCIR in the pathogenesis of AD, we used mice lacking DCIR (DCIR–/–) to generate a cockroach allergen–challenged mouse model of AD following the protocol illustrated in Figure 1A. Compared with WT mice, DCIR–/– mice exposed to cockroach allergen revealed the attenuation of allergen-induced skin inflammation, as defined by EASI score (Figure 5A) and histological analysis of epidermal thickness (Figure 5B). This evidence concerns the gene CLEC4A and Alzheimer disease.