CLEC4A and Alzheimer disease: Thus, we reconstituted KitW-sh/W-sh mice with BMMCs from WT and DCIR–/– mice via tail vein following the protocol as illustrated in Figure 6A. After 4 weeks, these reconstituted mice were used to generate cockroach allergen–induced AD models as previously illustrated in Figure 1A. The reconstituted mast cells in the lesional skin of the AD mouse model were confirmed by TB staining (Figure 6B).